Anthropic buys biotech startup Coefficient Bio in $400M deal (1 minute read)
Anthropic acquired biotech AI startup Coefficient Bio for $400 million in stock to bolster its healthcare and life sciences ventures. Coefficient Bio, founded by former Genentech researchers, used AI to expedite drug discovery and biological research. The 10-person team will integrate into Anthropic's health and life sciences division.
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Continual learning for AI agents (4 minute read)
Learning within AI agents can happen at the model, harness, or context layers. Understanding the difference can change how systems that improve over time are built. The model layer is the model weights themselves. The harness is the code, instructions, and tools that drive the agent. Context is the additional context that lives outside the harness for more configuration. Most people jump to the model when discussing continual learning, but in reality, an AI system can learn at all three of these levels.
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A Taxonomy of RL Environments for LLM Agents (17 minute read)
RL environments are training grounds for agents. Task distribution determines what skills agents develop, and harnesses control how they interact. Verifiers define what 'good' means. The state and configuration determine how realistic the training is.
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LLM Wiki (20 minute read)
This 'idea file', designed to be copied and pasted into an LLM agent, contains a pattern for building knowledge bases using LLMs. It helps LLMs incrementally build and maintain a persistent wiki that can be extended as the model continues learning. In this framework, the human curates sources, directs the analysis, asks questions, and thinks about what it all means, while the model does the rest. The agent makes edits based on conversations, and users can browse the changes in real-time.
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I Still Prefer MCP Over Skills (9 minute read)
The industry is pushing hard for Skills as the new standard for giving LLMs capabilities, but the Model Context Protocol (MCP) is a far superior, more pragmatic architectural choice. Skills are great for pure knowledge and teaching agents how to use an existing tool. MCPs give agents actual access to services, making them the right tool for the job in many cases.
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Embarrassingly Simple Self-Distillation Improves Code Generation (1 minute read)
Simple self-distillation (SSD) is a process where models are fine-tuned on samples of their output with standard supervised fine-tuning. It offers a complementary post-training direction for improving LLM code generation. SSD can improve code generation in models using only raw outputs. This study looks at why such a simple method can work.
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Meta-Harness: End-to-End Optimization of Model Harnesses (1 minute read)
The performance of large language model systems depends not just on model weights, but also on their harnesses. Meta-Harness is an outer-loop system that searches over harness code for LLM applications. Its harnesses surpass the best hand-engineered harnesses on agentic coding benchmarks. Meta-Harness shows how richer access to prior experience can enable automated harness engineering.
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Therefore I am. I Think (1 minute read)
LLMs often decide actions before generating reasoning tokens, influencing their chain of thought. A linear probe can decode these decisions from pre-generation activations with high accuracy.
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How to Build Your Second Brain (7 minute read)
A simple three-folder system (raw, wiki, and outputs) turns scattered notes into a structured, AI-maintained knowledge base using plain text files and a lightweight schema. Tools like agent-browser automate content ingestion, while AI compiles, links, and updates a personal wiki from raw inputs without manual organization. The system improves over time by saving outputs back into the loop and running periodic health checks to catch errors and gaps before they compound.
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